Manchester United's Alexis Sanchez misses training ahead of Juventus clash

Cristiano Ronaldo

As well as Mandzukic, Juventus will be without former Liverpool midfielder Emre Can for the game who is also recovering from injury.

Ronaldo, despite the turmoil of explosive rape allegations that surfaced before the worldwide break, notched up his fifth goal for his new employers since his headline move from Real Madrid in the 18th minute, ironically helped by a mistake from Genoa's top-scoring Polish striker Krzysztof Piatek. "I think Ronaldo learned from players like that". "All I'm thinking about is Manchester United".

Ronaldo is returning to Old Trafford for just the second time since he left United to join Madrid for a world record fee in 2009.

And Mourinho is well aware of the challenge he faces in setting up a defence that has conceded 16 times in the Premier League already this season to stop the top scorer in the Champions League for the past six seasons.

No specific reason has been given for Sanchez's absence, with Mourinho saying at his pre-match media conference: "The players you saw are the players that are available". "It's as simple as that".

The Italian champions have made a strong start to the season and sit top of the league, although they did drop their first points of the season on the weekend as they were held 1-1 by Genoa.

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"For the last five years or so they've been real contenders to win the title".

With eight Serie A wins and two in the Champions League Juve were all set to extend that fine run when Ronaldo put Massimiliano Allegri's men into a first-half lead.

Jose Mourinho's side ended a four-game winless run by coming from 2-0 down to beat Newcastle United 3-2 before the global break and were seconds away from ending Chelsea's unbeaten start to the season on Sunday until Ross Barkley salvaged a 2-2 draw.

"Then in the second half we did everything we said we wanted to do in the first half. We went from frantic to sleeping and vice versa".

He said: "The challenge of tomorrow is to win the game but we will do our best and see how we stand against one of the best teams in Europe".

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